FUBP1 (far upstream element binding protein 1) is a single-stranded nucleic acid-binding protein that primarily regulates MYC expression by binding to the far-upstream element (FUSE) sequence upstream of the MYC promoter 1. Beyond transcriptional regulation, FUBP1 functions as a general splicing factor that stabilizes key 3' splice site recognition components (U2AF2 and SF1) through multivalent binding interfaces, facilitating efficient splicing of long introns that comprise 80% of human introns 2. FUBP1 also regulates aerobic glycolysis in cancer cells 3. FUBP1 exhibits context-dependent roles in cancer with predominantly oncogenic functions. FUBP1 overexpression is associated with poor prognosis in cervical carcinoma, promoting cell proliferation and inhibiting apoptosis via enhanced DNA repair pathways 4. PRMT5-mediated methylation of FUBP1, regulated by BRD4, is crucial for prostate cancer progression and correlates with earlier biochemical recurrence 5. FUBP1 mutations occur in lower-grade gliomas with IDH mutations and 1p/19q codeletion, associated with favorable outcomes 6. FUBP1 is a candidate susceptibility gene for lung cancer 7. Recent evidence suggests FUBP1 plays a role in aging-related processes, with immune-cell-specific effects on telomere length and frailty 8. Targeting FUBP1 methylation or activity represents a potential therapeutic strategy across multiple cancer types.