FYCO1 (FYVE and coiled-coil domain autophagy adaptor 1) is an essential autophagy adaptor protein that mediates microtubule plus-end-directed transport of autophagosomes and regulates autophagosome maturation 12. The protein functions by binding to LC3 and facilitating the trafficking of autophagic vesicles along microtubules toward lysosomes for degradation 2. FYCO1 plays a critical role in maintaining lens homeostasis through autophagy-mediated clearance of damaged proteins, particularly α-crystallins 2. Loss-of-function mutations in FYCO1 result in impaired autophagic flux, accumulation of cellular organelles, and defective protein clearance 13. The primary disease association is autosomal recessive cataract formation, demonstrated across species including humans, mice, and dogs 241. In cataract pathogenesis, FYCO1 dysfunction leads to decreased LC3 conversion, accumulation of p62, and reduced soluble α-crystallin levels 2. Additionally, FYCO1 regulates cellular senescence through the PAK1/p21 pathway in lens epithelial cells 3. Beyond ocular function, FYCO1 has been implicated in cancer cell migration and invasion through CDC42/N-WASP/Arp2/3 signaling 5, and shows altered expression in VCP-related neurological disorders 6.