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GeneE
1 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
GATD1
glutamine amidotransferase class 1 domain containing 1
Chromosome 11 Β· 11p15.5
NCBI Gene: 347862Ensembl: ENSG00000177225.17HGNC: HGNC:26616UniProt: B7Z1J9
21PubMed Papers
15Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
extracellular exosomecytoplasmglyoxalase III activityearly endosomefemur fractureArthropathyaortic stenosisCOVID-19
✦AI Summary

Based on limited published evidence, GATD1 is a component of the FERRY (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary) complex 12. The complex functions as a RAB5A effector that directly interacts with mRNAs and mediates their endosomal transport and localization 1. GATD1 contributes to recruiting mRNAs and ribosomes to early endosomes, likely facilitating localized translation in cells with extensive cellular processes 3. While other FERRY complex members are associated with neurogenetic disorders, no mutations in GATD1 have yet been linked to disease 3.

Sources cited
1
GATD1 is a component of the FERRY complex that interacts with mRNAs and RAB5A to mediate endosomal mRNA transport
PMID: 37267905
2
GATD1 is part of the FERRY complex involved in mRNA localization and distribution
PMID: 37267906
3
GATD1 is a subunit of the FERRY complex proposed to shuttle mRNA for local translation; no neurogenetic disorders associated with GATD1 mutations have been reported
PMID: 40062705
⚠Limited data available β€” This gene has 3 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜15
femur fractureOpen Targets
0.11Weak
ArthropathyOpen Targets
0.09Suggestive
aortic stenosisOpen Targets
0.07Suggestive
COVID-19Open Targets
0.01Suggestive
Parkinson diseaseOpen Targets
0.01Suggestive
transaldolase deficiencyOpen Targets
0.01Suggestive
glioblastoma multiformeOpen Targets
0.00Suggestive
nervous system diseaseOpen Targets
0.00Suggestive
squamous cell carcinomaOpen Targets
0.00Suggestive
sickle cell diseaseOpen Targets
0.00Suggestive
attention deficit hyperactivity disorderOpen Targets
0.00Suggestive
gastric cancerOpen Targets
0.00Suggestive
ovarian serous cystadenocarcinomaOpen Targets
0.00Suggestive
sarcomaOpen Targets
0.00Suggestive
thyroid cancer, nonmedullary, 1Open Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
CRYZL1Protein interaction95%PPP1R21Protein interaction95%FERRY3Shared pathway50%TBCKShared pathway20%HNRNPABShared pathway14%PUM2Shared pathway8%
Tissue Expression6 tissues
Ovary
100%
Liver
81%
Lung
59%
Heart
53%
Brain
53%
Bone Marrow
37%
Gene Interaction Network
Click a node to explore
GATD1CRYZL1PPP1R21FERRY3TBCKHNRNPABPUM2
PROTEIN STRUCTURE
Preparing viewer…
PDB8A3P Β· 2.70 Γ… Β· X-ray
View on RCSB β†—
Constraintβ“˜
LOEUFβ“˜
1.49LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF1.03 [0.72–1.49]
RankingsWhere GATD1 stands among ~20K protein-coding genes
  • #13,915of 20,598
    Most Researched21
  • #15,107of 17,882
    Most Constrained (LOEUF)1.49
Genes detectedGATD1
Sources retrieved1 papers
Response timeβ€”
πŸ“„ Sources
1
1
Neurogenetic disorders associated with mutations in the FERRY complex: a novel disease class?
PMID: 40062705
Biol Open Β· 2025
1.00