1 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
βGeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
21PubMed Papers
15Diseases
0Drugs
0Pathogenic Variants
DATA QUALITYβ Experimental GO Evidenceβ Swiss-Prot Reviewed
extracellular exosomecytoplasmglyoxalase III activityearly endosomefemur fractureArthropathyaortic stenosisCOVID-19
Based on limited published evidence, GATD1 is a component of the FERRY (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary) complex 12. The complex functions as a RAB5A effector that directly interacts with mRNAs and mediates their endosomal transport and localization 1. GATD1 contributes to recruiting mRNAs and ribosomes to early endosomes, likely facilitating localized translation in cells with extensive cellular processes 3. While other FERRY complex members are associated with neurogenetic disorders, no mutations in GATD1 have yet been linked to disease 3.
1
GATD1 is a component of the FERRY complex that interacts with mRNAs and RAB5A to mediate endosomal mRNA transport
PMID: 372679052
GATD1 is part of the FERRY complex involved in mRNA localization and distribution
PMID: 372679063
GATD1 is a subunit of the FERRY complex proposed to shuttle mRNA for local translation; no neurogenetic disorders associated with GATD1 mutations have been reported
PMID: 40062705β Limited data available β This gene has 3 indexed publications. Summary and analysis may be incomplete.
femur fractureOpen Targets
aortic stenosisOpen Targets
Parkinson diseaseOpen Targets
transaldolase deficiencyOpen Targets
glioblastoma multiformeOpen Targets
nervous system diseaseOpen Targets
squamous cell carcinomaOpen Targets
sickle cell diseaseOpen Targets
attention deficit hyperactivity disorderOpen Targets
gastric cancerOpen Targets
ovarian serous cystadenocarcinomaOpen Targets
thyroid cancer, nonmedullary, 1Open Targets
No pathogenic variants reported on ClinVar for this gene.