HNRNPAB (heterogeneous nuclear ribonucleoprotein A/B) is an RNA-binding protein that plays critical roles in cancer progression and viral defense mechanisms. The protein primarily functions by binding to and stabilizing oncogenic mRNAs, including MYC and CDK4, thereby promoting tumor cell proliferation and metastasis 12. HNRNPAB enhances cancer stem cell properties and chemotherapy resistance in colorectal cancer by maintaining stemness markers and reducing sensitivity to 5-fluorouracil and oxaliplatin 3. The protein promotes metastasis through multiple mechanisms, including stabilization of MYC mRNA leading to CXCL8 secretion and neutrophil recruitment in pancreatic cancer 1, and regulation of epithelial-mesenchymal transition in hepatocellular carcinoma through transcriptional repression of tumor suppressor lncRNA-ELF209 4. Clinically, HNRNPAB overexpression correlates with poor prognosis across multiple cancer types including gastric, pancreatic, and lung adenocarcinomas 516. Notably, HNRNPAB also functions as an antiviral factor against influenza A virus by disrupting viral polymerase activity through interference with PB1-NP protein interactions 7. The protein's dysregulation is also implicated in gestational diabetes mellitus, suggesting broader physiological roles 8.