GCFC2 (GC-rich sequence DNA-binding factor 2) is a nuclear protein involved in pre-mRNA splicing through regulation of spliceosome C complex formation 1. The gene localizes to chromosome 2.1-11.2 2 and plays a role in late-stage splicing events and excised intron turnover 1. GCFC2 has been implicated in neurodevelopmental disorders affecting language and literacy. Genetic studies identified GCFC2 variants as contributing to language traits in children with autism spectrum disorders 3, and it was included among candidate genes examined in specific learning disorder families, though causative effects were not definitively established 4. Additionally, GCFC2 variants were associated with hippocampal volume in Alzheimer's disease genome-wide association studies 5, suggesting broader neurological relevance. The protein's association with splicing machinery links it to proper spliceosomal complex assembly, which is critical for normal gene expression. While GCFC2's core biochemical function centers on splicing regulation, its genetic associations with neurodevelopmental and neurodegenerative conditions suggest important roles in maintaining normal brain structure and language-cognitive function, though the mechanistic connections require further investigation.