Based on limited published evidence, CWF19L2 is a nucleoplasmic protein involved in mRNA splicing and post-mRNA release spliceosomal processes. CWF19L2 functions as a critical component of the intron lariat spliceosome, where it interacts with splicing machinery including DBR1, NVL2, and the RNA exosome complex 1. The protein is required for debranching of intron-derived lariat RNAs, facilitating their nuclear clearance 1. Genomic studies suggest CWF19L2 involvement in cell cycle regulation 2. The protein shares C-terminal homology with yeast Cwf19 and mammalian CWF19L1 1.