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6 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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GFY
golgi associated olfactory signaling regulator
Chromosome 19 · 19q13.33
NCBI Gene: 100507003Ensembl: ENSG00000261949.7HGNC: HGNC:44663UniProt: I3L273
3PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
sensory perception of smellGolgi membraneGolgi apparatusalcohol drinkingKallmann syndromeLeber congenital amaurosis 10hypogonadotropic hypogonadism
✦AI Summary

Insufficient information is available to provide a comprehensive gene function summary for GFY (golgi associated olfactory signaling regulator). The provided PubMed abstracts do not contain relevant data on GFY function, mechanism, or disease relevance. One abstract mentions GFY in the context of an exome-wide association study identifying genetic variants associated with early-onset coronary artery disease in a Japanese population 1, where GFY was identified as one of 21 genes newly associated with CAD susceptibility. However, this abstract provides only the gene name without mechanistic details or functional characterization. The remaining abstracts address unrelated topics (pediatric trauma resuscitation, congestive heart failure mortality, COVID-19 treatment, hydatid disease, and climate change) and contain no information about GFY. To provide an adequate summary of GFY's primary function in olfactory signaling, its mechanism at the Golgi membrane, and its clinical significance, peer-reviewed literature specifically investigating GFY's molecular and cellular functions would be required.

Sources cited
1
GFY was identified as one of 21 genes newly associated with susceptibility to early-onset coronary artery disease in a Japanese population through exome-wide association studies
PMID: 30402224
⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
Disease Associationsⓘ20
alcohol drinkingOpen Targets
0.18Weak
Kallmann syndromeOpen Targets
0.05Suggestive
Leber congenital amaurosis 10Open Targets
0.05Suggestive
hypogonadotropic hypogonadismOpen Targets
0.05Suggestive
Absent thumb - short stature - immunodeficiencyOpen Targets
0.04Suggestive
asthma, nasal polyps, and aspirin intoleranceOpen Targets
0.04Suggestive
Abnormality of the earOpen Targets
0.04Suggestive
obstructive sleep apneaOpen Targets
0.04Suggestive
hypogonadotropic hypogonadism 21 with or without anosmiaOpen Targets
0.03Suggestive
hypogonadotropic hypogonadism 14 with or without anosmiaOpen Targets
0.03Suggestive
hypogonadotropic hypogonadism 27 without anosmiaOpen Targets
0.03Suggestive
hypogonadotropic hypogonadism 5 with or without anosmiaOpen Targets
0.03Suggestive
atherosclerosisOpen Targets
0.00Suggestive
cardiovascular diseaseOpen Targets
0.00Suggestive
posterior cortical atrophyOpen Targets
0.00Suggestive
breast cancerOpen Targets
0.00Suggestive
AnxietyOpen Targets
0.00Suggestive
chronic kidney diseaseOpen Targets
0.00Suggestive
hypertensionOpen Targets
0.00Suggestive
HypertriglyceridemiaOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
OMPShared pathway50%OBP2BShared pathway50%TAAR9Shared pathway50%TAAR6Shared pathway50%OR8U9Shared pathway50%OR8U8Shared pathway50%
Tissue Expression6 tissues
Brain
100%
Bone Marrow
6%
Lung
0%
Ovary
0%
Heart
0%
Liver
0%
Gene Interaction Network
Click a node to explore
GFYOMPOBP2BTAAR9TAAR6OR8U9OR8U8
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted · UniProt I3L273
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
1.28LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF0.94 [0.69–1.28]
RankingsWhere GFY stands among ~20K protein-coding genes
  • #18,866of 20,598
    Most Researched3
  • #13,524of 17,882
    Most Constrained (LOEUF)1.28
Genes detectedGFY
Sources retrieved6 papers
Response time—
📄 Sources
6▼
1
Identification of 26 novel loci that confer susceptibility to early-onset coronary artery disease in a Japanese population.
PMID: 30402224
Biomed Rep · 2018
1.00
2
Classification and team response to nonroutine events occurring during pediatric trauma resuscitation.
PMID: 27648769
J Trauma Acute Care Surg · 2016
0.83
3
Sex-specific differences in the association between steps per day and all-cause mortality among a cohort of adult patients from the United States with congestive heart failure.
PMID: 37541137
Heart Lung · 2023
0.67
4
Corticosteroid therapy for coronavirus disease 2019-related acute respiratory distress syndrome: a cohort study with propensity score analysis.
PMID: 33172477
Crit Care · 2020
0.50
5
Coexisting Primary Ovarian and Omental Hydatid Disease Mimicking an Ovarian Neoplasm: A Case Report.
PMID: 28700426
Int J Gynecol Pathol · 2018
0.33