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10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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OMP
olfactory marker protein
Chromosome 11 · 11q13.5
NCBI Gene: 4975Ensembl: ENSG00000254550.1HGNC: HGNC:8136UniProt: P47874
16PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
axonneuronal cell bodysensory perception of smellnucleusmelanomainfectionexperimental autoimmune encephalomyelitisnon-small cell lung carcinoma
✦AI Summary

Based on the provided abstracts, information about the olfactory marker protein (OMP) gene is extremely limited. The gene encodes a 19 kDa protein that is highly restricted to mature olfactory receptor neurons across vertebrate species 1. OMP participates in the olfactory signal transduction pathway, as evidenced by behavioral and electrophysiological deficits in OMP-null mice that can be reversed by intranasal infection with OMP-expressing adenovirus 2. The protein can form a 38 kDa homodimer through covalent cross-linking, with the dimer being much less stable than the monomer and preferentially located in a cytoskeletal fraction 2. OMP expression is regulated by transcription factor Foxj1, which controls both olfactory cilia biogenesis and OSN differentiation, with OMP being involved in odor-evoked signal transduction 3. The OMP gene structure is highly conserved between species, lacking canonical TATA and CAAT motifs and introns, with the protein sequence being 88.4% identical between mouse and human 1. However, the specific molecular mechanism by which OMP modulates olfactory signaling remains unclear from the available literature.

Sources cited
1
OMP expression is highly restricted to mature olfactory receptor neurons and gene structure is conserved across species
PMID: 8034318
2
OMP participates in olfactory signal transduction pathway and forms homodimers with different stability and localization properties
PMID: 15198671
3
OMP expression is regulated by Foxj1 and is involved in odor-evoked signal transduction
PMID: 38271330
⚠Limited data available — This gene has 3 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
melanomaOpen Targets
0.05Suggestive
infectionOpen Targets
0.03Suggestive
experimental autoimmune encephalomyelitisOpen Targets
0.03Suggestive
non-small cell lung carcinomaOpen Targets
0.02Suggestive
acquired thrombocytopeniaOpen Targets
0.02Suggestive
Toriello-Lacassie-Droste syndromeOpen Targets
0.02Suggestive
Lyme diseaseOpen Targets
0.02Suggestive
neoplasmOpen Targets
0.02Suggestive
cancerOpen Targets
0.02Suggestive
schizophreniaOpen Targets
0.02Suggestive
colorectal cancerOpen Targets
0.02Suggestive
allergic rhinitisOpen Targets
0.02Suggestive
achalasia-alacrima syndromeOpen Targets
0.02Suggestive
ParkinsonismOpen Targets
0.02Suggestive
ulcer diseaseOpen Targets
0.02Suggestive
myeloid sarcomaOpen Targets
0.01Suggestive
Pituitary prolactin cell adenomaOpen Targets
0.01Suggestive
Salmonella InfectionsOpen Targets
0.01Suggestive
brucellosisOpen Targets
0.01Suggestive
hyperthyroidismOpen Targets
0.01Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
ADCY3Protein interaction94%CNGA2Protein interaction77%GAP43Protein interaction77%MYO7AProtein interaction75%TMTC1Protein interaction71%BEX1Protein interaction70%
Tissue Expression6 tissues
Liver
100%
Bone Marrow
67%
Ovary
10%
Brain
7%
Lung
5%
Heart
0%
Gene Interaction Network
Click a node to explore
OMPADCY3CNGA2GAP43MYO7ATMTC1BEX1
PROTEIN STRUCTURE
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AlphaFoldAI-predicted · UniProt P47874
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
0.95LoF Tolerant
pLIⓘ
0.13Tolerant
Observed/Expected LoF0.48 [0.26–0.95]
RankingsWhere OMP stands among ~20K protein-coding genes
  • #15,333of 20,598
    Most Researched16
  • #8,870of 17,882
    Most Constrained (LOEUF)0.95
Genes detectedOMP
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
The one-minute preceptor model: A systematic review.
PMID: 30431548
J Am Assoc Nurse Pract · 2019
1.00
2
Use of bidirectional Mendelian randomization to unveil the association of
PMID: 39083605
Sci Adv · 2024
0.90
3
Targeting the Wnt pathway in human cancers: therapeutic targeting with a focus on OMP-54F28.
PMID: 25172549
Pharmacol Ther · 2015
0.80
4
Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization.
PMID: 8034318
Genomics · 1994
0.70
5
The interaction of Bex and OMP reveals a dimer of OMP with a short half-life.
PMID: 15198671
J Neurochem · 2004
0.60