GGA2 is a Golgi-associated adaptor protein that plays crucial roles in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. The protein mediates ARF-dependent recruitment of clathrin to the TGN and binds cargo molecules containing acidic cluster-dileucine motifs 1. GGA2 facilitates forward trafficking of membrane proteins, including GPCRs like α2B-adrenergic receptor to the cell surface 2, and promotes activity-dependent β1-integrin recycling in cooperation with RAB13 3. The protein is essential for proper lysosomal enzyme sorting, as GGA2 depletion causes cathepsin D missorting and increased secretion 4. GGA2 also regulates EGFR stability by interacting with the receptor's cytoplasmic domain, preventing its lysosomal degradation and maintaining steady-state expression levels 5. Additionally, GGA2 controls phosphatidylinositol 4-kinase localization at the TGN, which is critical for PtdIns4P synthesis and subsequent clathrin adaptor recruitment 6. Clinically, GGA2 is amplified in lung adenocarcinomas with EGFR mutations and overexpressed in hepatocellular and colorectal cancers, where it cooperatively drives tumor progression by enhancing EGFR signaling 7.