GGA3 is a clathrin adaptor protein that mediates protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes through ARF-dependent mechanisms 1. The short form of GGA3 predominates in most human tissues except brain 2. GGA3 functions in multiple trafficking pathways: it mediates export of GPCRs including α2B-adrenergic receptors to the cell surface through interaction with receptor intracellular loops and its VHS domain 1, regulates recycling of the DP1 prostaglandin receptor via Rab4-dependent mechanisms and requires L-type prostaglandin D synthase 3, and controls RET51 receptor recycling through ARF6 interaction to promote cell migration and invasion 4. GGA3 also mediates CI-MPR trafficking through a CK2-phosphorylation cascade involving PACS-1 5 and regulates β1 integrin trafficking by controlling SNX17 endosomal localization, directing integrins from degradation toward recycling to support cell migration 6. Notably, GGA1 and GGA3 appear to promote EGFR degradation, opposing GGA2's stabilizing function 7. These diverse trafficking roles establish GGA3 as a key coordinator of receptor endosomal sorting with broad implications for cell signaling and migration.