GHRH (growth hormone releasing hormone) is a hypothalamic neuropeptide hormone that primarily stimulates growth hormone (GH) secretion from the anterior pituitary gland through binding to GHRH receptors (GHRH-R) 1. The hormone activates G protein-coupled receptors and triggers adenylyl cyclase/cAMP/PKA signaling pathways, as well as Ras/Raf/ERK, PI3K/Akt/mTOR, and JAK2/STAT3 pathways involved in cell survival and proliferation 2. Beyond its classical endocrine function, GHRH is expressed in extrapituitary tissues including pancreas, prostate, and various cancers, where it promotes cell proliferation through pituitary-type receptors and splice variants 34. GHRH also participates in sleep regulation, acting as a sleep-promoting factor that enhances slow-wave sleep 5. Clinically, GHRH has therapeutic potential in multiple conditions: GHRH agonists show promise for treating GH deficiency and enhancing pancreatic β-cell survival in diabetes 41, while GHRH antagonists demonstrate anticancer, anti-inflammatory, and antioxidant activities in various malignancies including prostate, breast, and lung cancers 36. The hormone's diverse signaling mechanisms and tissue distribution make it a valuable therapeutic target across endocrinology, oncology, and metabolic diseases.