GIMAP8 is a GTPase belonging to the immunity-associated protein family that primarily functions in immune system regulation and anti-apoptotic processes. The protein exhibits GTPase activity and localizes to the endoplasmic reticulum 1. GIMAP8 demonstrates significant roles in cancer biology, showing reduced expression in various tumor tissues including lung adenocarcinoma, breast cancer, and non-small cell lung cancer compared to normal tissues 123. This downregulation correlates with poor prognosis, as patients with higher GIMAP8 expression show improved overall survival 12. The gene's expression is closely associated with immune cell infiltration, including B cells, CD4+ T cells, CD8+ T cells, macrophages, neutrophils, and dendritic cells 2. GIMAP8 also influences tumor radiation resistance and is linked to immune-related signaling pathways including NF-κB, chemokine, and cell adhesion molecule pathways 1. In women with trisomy 21, GIMAP8 upregulation may contribute to protection against breast cancer development 4. Additionally, GIMAP8 has been identified as a potential biomarker in salt-sensitive hypertension and participates in ceRNA regulatory networks 5. A novel KMT2A/GIMAP8 fusion has been reported in acute undifferentiated leukemia 6.