GLMP (glycosylated lysosomal membrane protein) is a crucial accessory subunit that forms a tight complex with the lysosomal transporter MFSD1 in the lysosomal membrane 1 2. GLMP's primary function is to protect MFSD1 from lysosomal proteolysis and ensure its proper lysosomal localization 2. The luminal domain of GLMP, particularly its N-glycosylation, is essential for this protective interaction, though the specific type of N-glycans is not critical 2. The MFSD1-GLMP complex functions as a general dipeptide uniporter, facilitating the transport of cationic, neutral, and anionic dipeptides across lysosomal membranes 1. GLMP also participates in a larger protein complex with GIMAP5, which is essential for lymphocyte survival and liver homeostasis 3. In disease contexts, GLMP demonstrates clinical significance in multiple cancers. Its mRNA is stabilized by NAT10-mediated N4-acetylcytidine modification, promoting metastasis in head and neck squamous cell carcinoma through MAPK/ERK signaling 4. GLMP expression is regulated by BRG1 and influences lipid metabolism in hepatocellular carcinoma via the PIK3AP1/PI3K/AKT pathway 5. Additionally, GLMP serves as a potential ferroptosis-related biomarker for hepatocellular carcinoma prognosis 6.