GLP2R encodes the glucagon-like peptide-2 receptor, a G protein-coupled receptor that mediates the biological effects of GLP-2, a 33-amino acid peptide hormone co-secreted with GLP-1 from enteroendocrine L cells 1. The receptor signals through G proteins that activate adenylyl cyclase and is particularly expressed in the gastrointestinal tract, liver, adipose tissue, and central nervous system 1. GLP2R plays crucial roles in intestinal homeostasis, promoting intestinal mucosal proliferation, improving gut barrier function, and enhancing mesenteric blood flow 1. In hepatic stellate cells, GLP2R signaling appears protective against liver disease, as Glp2r-/- mice show increased hepatic lipid accumulation, inflammation, and stellate cell activation 2. The receptor has clinical significance in metabolic diseases, with a variant (p.Asp470Asn) associated with altered citrulline levels, BMI, and type 2 diabetes through β-arrestin signaling mechanisms 3. Additionally, GLP2R expression is upregulated in EGFR-TKI resistant lung cancer cells, potentially affecting treatment sensitivity 4. The receptor's gut barrier-promoting and anti-inflammatory effects make it a potential therapeutic target for obesity and related metabolic complications 1.