GLRA2 encodes the glycine receptor alpha 2 subunit, a component of heteromeric glycine-gated chloride channels that mediate inhibitory neurotransmission 1. As a ligand-gated ion channel, GLRA2 contributes to generating inhibitory postsynaptic currents and down-regulating neuronal excitability 2. Beyond synaptic inhibition, GLRA2 plays critical developmental roles: GlyR α2 is essential for cortical interneuron migration and progenitor homeostasis, promoting generation of excitatory projection neurons in the embryonic brain 13. The gene also participates in synaptic plasticity and cellular responses to ethanol 41. Pathogenic GLRA2 variants cause early-onset high myopia (eoHM) through impaired photoperception and visual transmission, with myopia transmitted via X-linked inheritance and manifesting as mild cone impairment 56. GLRA2 mutations also associate with neurodevelopmental disorders including autism spectrum disorder, developmental delay, and intellectual disability, often accompanied by microcephaly, language delay, and epilepsy 13. Loss-of-function mutations impair GLRA2 membrane localization and glycine sensitivity, causing deficits in object recognition memory and long-term potentiation 1. GLRA2 was identified as a candidate gene in X-chromosome X association studies 7.