GRPR (gastrin-releasing peptide receptor) is an X-linked G protein-coupled receptor that signals through phosphatidylinositol-calcium pathways and Akt phosphorylation 1. Functionally, GRPR mediates diverse roles across multiple neural circuits. In sensory processing, GRPR is central to itch sensation; spinal neurons expressing GRPR function as key convergent circuits for transmitting peripheral itch information to the brain, with GRP identified as an itch-specific neuropeptide distinct from pain pathways 2. GRPR regulates multiple homeostatic and behavioral functions including food intake, body temperature, memory and cognition, fear responses, depression and anxiety, circadian rhythms, and sighing behavior through modulation of specific brain nuclei including the amygdala, hypothalamus, preBötzinger complex, and suprachiasmatic nucleus 1. Clinically, GRPR has emerged as a cancer target: in melanoma and other E-cadherin-deficient cancers, GRPR participates in an oestrogen-sensitizing pathway that promotes tumor aggressiveness specifically in premenopausal women, and GRPR inhibition reduces metastasis in preclinical models 3. This G protein-coupled receptor thus represents a potential therapeutic target for sex-hormone-dependent cancers and conditions involving itch dysregulation.