GML (glycosylphosphatidylinositol anchored molecule-like protein) is a p53-inducible gene located on human chromosome 8.3 1. As a GPI-anchored protein, GML is positioned at the plasma membrane where it plays a role in p53-mediated cellular responses to DNA damage 1. GML functions as a mediator of apoptosis and cell-cycle regulation downstream of p53, contributing to negative regulation of cell proliferation 1. Mechanistically, GML expression correlates with enhanced sensitivity to chemotherapeutic agents; colorectal cancer cells expressing GML demonstrate increased sensitivity to mitomycin C and 5-fluorouracil, suggesting GML promotes chemotherapy-induced cell death 2. Introduction of GML cDNA into cells lacking endogenous expression enhanced their chemosensitivity, demonstrating GML's functional role in drug response 2. Clinically, GML and p53 mutation status may serve as predictive biomarkers for chemotherapy response in colorectal cancer patients 2. The chromosome 8.3 locus harboring GML is frequently amplified in human cancers, and GML belongs to the LY6 gene family with emerging roles in cancer progression and immune regulation 3.