GOLGA2 (golgin A2) is a peripheral membrane protein of the cis-Golgi that functions as both a structural scaffolding component and vesicle tether. Its primary role is maintaining Golgi apparatus architecture and facilitating vesicle fusion through interactions with p115/USO1 and STX5 1. GOLGA2 is essential for ER-to-Golgi protein transport and requires phosphorylation at Ser-37 by CDK1 during mitosis to inhibit p115 interaction, thereby suppressing Golgi transport during cell division 1. Beyond vesicle trafficking, GOLGA2 plays a critical role in mitotic spindle assembly by recruiting the spindle assembly factor TPX2 through importin-alpha interactions at the Golgi membrane, enabling microtubule nucleation and capture 2. The protein also regulates meiotic spindle pole and centrosome organization through similar mechanisms 2. GOLGA2 connects the Golgi network to autophagy regulation, serving as a docking site for RAB2 and GABARAP, thereby linking membrane trafficking to autophagic pathway initiation 34. Clinically, GOLGA2 mutations are associated with developmental delay accompanied by hypotonia, myopathy, and brain abnormalities 1. These pleiotropic functions—spanning membrane trafficking, cell division machinery organization, and autophagy regulation—underscore GOLGA2's significance in coordinating multiple cellular processes essential for normal development and neural function.