SEC22A is a vesicle trafficking protein functioning as a SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) involved in endoplasmic reticulum-to-Golgi transport. As a v-SNARE homolog of yeast Sec22p 1, SEC22A participates in membrane fusion machinery alongside other SNARE proteins including syntaxin 5, membrin, and rbet1 2. The protein localizes to the ER and interacts with regulatory proteins such as VAP-A, which binds promiscuously to multiple SNAREs including SEC22A (rsec22) 3. SEC22A is emerging as functionally significant beyond canonical trafficking. It associates with RAB18, a small GTPase implicated in membrane contact site regulation and cholesterol biosynthesis 4. Recent evidence indicates SEC22A mediates transport and localization of head-tail coupling apparatus proteins during spermatogenesis, with ARRDC5 affecting SEC22A-dependent positioning of NDC1 and SUN5 5. Therapeutically, enhancing SEC22A expression in neurons has been proposed as a strategy to prevent synucleinopathies like Parkinson's disease, as SEC22A suppresses α-synuclein toxicity 6. SEC22A's regulatory genomic context near ADCY5 in pancreatic islets suggests potential roles in glucose metabolism, though SEC22A expression itself appears independent of ADCY5-regulating enhancer variants 7.