LMAN1L (lectin, mannose binding 1 like) is a mannose-binding lectin localized to the endoplasmic reticulum-Golgi intermediate compartment and involved in ER-to-Golgi vesicle-mediated transport 1. The gene encodes a member of the L-type lectin family with predicted roles in the early secretory pathway and glycoprotein trafficking 1. Clinically, LMAN1L has emerged as a candidate biomarker in multiple cancer types. In lung squamous cell carcinoma, a novel susceptibility locus was identified at LMAN1L (15q24.1) in African American populations through genome-wide association studies 2. In pancreatic ductal adenocarcinoma, LMAN1L was screened as a candidate biomarker and potential therapeutic target through integrated mRNA and protein expression analysis 3. Most significantly, in triple-negative breast cancer, LMAN1L was identified as a novel glycosylation-related prognostic gene where low expression significantly inhibited cancer cell proliferation and migration, suggesting therapeutic potential 4. Additionally, LMAN1L was associated with neuroticism in genetic studies of personality traits 5, and showed epigenetic modifications in hypospadias cases 6. These findings suggest LMAN1L functions in cellular transport while also serving as a prognostic marker in cancer biology.