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GeneE
2 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
GOLGA8N
golgin A8 family member N
Chromosome 15 Β· 15q13.3
NCBI Gene: 643699Ensembl: ENSG00000232653.9HGNC: HGNC:44405UniProt: F8WBI6
4PubMed Papers
3Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
Golgi organizationGolgi cis cisternacis-Golgi networkGolgi cisterna membranealcohol drinkingmemory impairmentosteoporosis-pseudoglioma syndrome
✦AI Summary

Based on limited published evidence, GOLGA8N is a golgin A8 family member localized to the cis-Golgi network, Golgi cisterna, and Golgi cisterna membrane, where it functions in Golgi organization. Two bioinformatics studies identified GOLGA8N as one of five key genes associated with osteoporosis, suggesting a potential role in glutamine and pyrimidine metabolism pathways relevant to bone disease 12. However, the mechanistic basis for GOLGA8N's involvement in osteoporosis and its specific metabolic functions remain unclear.

Sources cited
1
GOLGA8N identified as a glutamine metabolism-related gene associated with osteoporosis and proposed as a diagnostic biomarker
PMID: 37710308
2
GOLGA8N identified as a pyrimidine metabolism-related gene linked to osteoporosis with diagnostic potential
PMID: 38778304
⚠Limited data available β€” This gene has 2 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜3
alcohol drinkingOpen Targets
0.09Suggestive
memory impairmentOpen Targets
0.09Suggestive
osteoporosis-pseudoglioma syndromeOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
GOLGA8RShared pathway100%GOLGA8HShared pathway100%GOLGA8OShared pathway100%GOLGA8QShared pathway100%GOLGA8MShared pathway100%GOLGA6DShared pathway100%
Tissue Expression6 tissues
Ovary
100%
Liver
59%
Lung
38%
Bone Marrow
20%
Brain
18%
Heart
3%
Gene Interaction Network
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GOLGA8NGOLGA8RGOLGA8HGOLGA8OGOLGA8QGOLGA8MGOLGA6D
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt F8WBI6
View on AlphaFold β†—
RankingsWhere GOLGA8N stands among ~20K protein-coding genes
  • #18,577of 20,598
    Most Researched4
Genes detectedGOLGA8N
Sources retrieved2 papers
Response timeβ€”
πŸ“„ Sources
2
1
Bioinformatics and machine learning were used to validate glutamine metabolism-related genes and immunotherapy in osteoporosis patients.
PMID: 37710308
J Orthop Surg Res Β· 2023
1.00
2
Integration of bioinformatics and machine learning approaches for the validation of pyrimidine metabolism-related genes and their implications in immunotherapy for osteoporosis.
PMID: 38778304
BMC Musculoskelet Disord Β· 2024
0.50