GOLT1A (Golgi transport 1A) is a membrane-associated protein involved in vesicular transport between the endoplasmic reticulum and Golgi complex 1. While its precise molecular function in normal physiology remains incompletely characterized, GOLT1A has emerged as a significant factor in cancer biology and disease pathogenesis. In adenoid cystic carcinoma, GOLT1A-KISS1 gene fusion blocks translation of the metastasis suppressor KISS1 through introduction of upstream open reading frames, promoting tumor metastasis 2. GOLT1A is upregulated in multiple cancer types and associates with poor prognosis. In lung adenocarcinoma, lidocaine suppresses GOLT1A expression to inhibit cell proliferation and invasion 3. High GOLT1A expression correlates with poor prognosis in papillary thyroid carcinoma, associating with lymph node metastasis and reduced differentiation 4. In breast cancer, downregulation of GOLT1A by miR-378a-3p enhances tamoxifen sensitivity and improves survival outcomes 5. GOLT1A also functions as a plasma membrane tension-related gene influencing cell migration in bladder cancer 6. Genomically, GOLT1A resides within a topologically associated domain on chromosome 1.1, separated from neighboring genes by CTCF-binding insulator sites 78. These regulatory elements may degrade with aging, potentially contributing to disease development.