GOPC (Golgi-associated PDZ and coiled-coil motif containing) is a Golgi-resident trafficking protein that regulates intracellular protein localization and degradation 123. GOPC functions as a molecular platform for controlling plasma membrane expression of multiple proteins, including ion channels and receptors, by modulating their trafficking through the trans-Golgi network and endosomal-lysosomal pathways 4. The protein plays a critical role in insulin secretion by regulating SNAP25 plasma membrane localization at the trans-Golgi network 4. GOPC is also implicated in autophagy-related degradation pathways, particularly through ubiquitin-mediated lysosomal degradation of substrates like CFTR 5. Clinically, GOPC dysfunction is associated with disease pathogenesis in multiple contexts: oncogenic GOPC-ROS1 fusion mutations drive lymphatic malformation formation and mediate tyrosine kinase signaling 67, and GOPC is targeted for degradation by HSV-1 pUL56, enabling viral evasion of immune responses through altered cell-surface receptor expression 8. Additionally, altered GOPC expression correlates with preeclampsia pathology 9, suggesting broader roles in vascular and metabolic diseases.