GORAB is a golgin protein localized to the trans-Golgi network that functions as a critical regulator of vesicular transport and protein glycosylation 1. It interacts with small GTPases RAB6 and ARF5 through its IGRAB domain to facilitate Golgi targeting and membrane association 2. GORAB also associates with vimentin intermediate filaments to provide structural stability to the Golgi complex 3. Beyond Golgi functions, GORAB is required for primary cilium formation and hedgehog signaling during hair follicle morphogenesis 4, and localizes to the centriole cartwheel where it functions in centriole duplication 5. During lung development, GORAB negatively regulates AKT phosphorylation and versican expression to control mesenchymal cell migration and alveolar sac maturation 6. Loss-of-function GORAB mutations cause gerodermia osteodysplastica (GO), a segmental progeroid disorder featuring wrinkled skin, early-onset osteoporosis, and bone fragility 12. GO pathogenesis involves glycosaminoglycan chain shortening and extracellular matrix disorganization, triggering a TGF-β-Nox4-cellular senescence axis that drives osteoporosis 1. Bone from GO mouse models exhibits decreased mineralization, reduced strength, and increased brittleness resembling skeletal aging 7.