GOT1L1 (glutamic-oxaloacetic transaminase 1-like 1) is a cytosolic protein with putative transaminase activity that catalyzes L-aspartate:2-oxoglutarate reactions and participates in L-aspartate biosynthesis. Despite initial proposals that GOT1L1 functions as an aspartate racemase producing D-aspartate from L-aspartate 1, subsequent investigations demonstrated that rat and human GOT1L1 homologs are not responsible for D-aspartate biosynthesis 1, suggesting the actual metabolic role of this enzyme remains incompletely characterized. GOT1L1 has emerging relevance in hematologic malignancies. Ectopic expression of GOT1L1, as part of a 5-gene signature (5-GEC), is significantly associated with high-risk T-cell acute lymphoblastic leukemia (T-ALL) and predicts poor treatment response, including positive minimal residual disease or short-term relapse in MRD-negative patients 2. GOT1L1-positive T-ALL cases demonstrate drastic shutdown of mitochondrial genome expression and histone gene upregulation 2. SOmatic GOT1L1 mutations have been identified in rare inflammatory conditions, including malakoplakia, though their pathogenic significance remains unclear 3. Further investigation is needed to fully elucidate GOT1L1's metabolic function and mechanisms underlying its association with aggressive leukemia.