Based on limited published evidence, LDHAL6A encodes a lactate dehydrogenase-like protein that catalyzes the interconversion of L-lactate and pyruvate using NAD+ as a coenzyme 1. The protein localizes to the cytoplasm and mitochondria, and significantly increases JUN transcriptional activity when overexpressed 1. Recent evidence identifies LDHAL6A as an exosomal effector that promotes malignant programs in recipient cells, with inhibition combined with paclitaxel suppressing triple-negative breast cancer growth and metastasis 2. The gene participates in lactate and pyruvate metabolism.