Based on limited published evidence, LDHAL6B encodes a lactate dehydrogenase A-like protein localized to the cytoplasm, nucleus, and mitochondrial matrix. UniProt annotations indicate L-lactate dehydrogenase (NAD+) activity and involvement in lactate metabolic processes, pyruvate catabolism, and pyruvate fermentation to lactate. LDHAL6B associates with protein binding functions. In vivo studies demonstrated that Ldhal6b knockout mice remained fertile, suggesting the gene is not essential for male reproduction when individually ablated 1.