GPR157 is an orphan G protein-coupled receptor that functions as a promoter of neuronal differentiation in radial glial progenitors through Gq-protein-mediated activation of phosphatidylinositol-calcium signaling pathways. The receptor localizes to ciliary membranes and plasma membranes, where it regulates phospholipase C-activating signaling cascades involved in radial glial cell differentiation. Regarding disease relevance, GPR157 does not appear to harbor pathogenic mutations in Schnyder crystalline corneal dystrophy, as screening of affected families identified only novel single nucleotide polymorphisms without functional significance 1. However, emerging evidence suggests GPR157 has oncological implications. The gene was identified as a potential prognostic biomarker for endometrioid endometrial carcinoma, where estradiol-regulated miR-30a-5p suppression of GPR157 expression is associated with patient outcomes 2. Similarly, in glioblastoma, GPR157 upregulation correlated with decreased overall survival, and the combination of A2BP1 and GPR157 was proposed as a diagnostic marker, with GPR157 designated a prognostic biomarker among G protein-coupled receptors dysregulated in this aggressive malignancy 3. Clinically, GPR157 represents a novel therapeutic target in estradiol-dependent cancers and may inform personalized treatment strategies in glioblastoma based on expression profiling.