GPR179 is an orphan class C G protein-coupled receptor essential for retinal vision, specifically required for signal transduction through ON-bipolar cells 1. Localized to the dendritic tips of ON-bipolar cells, GPR179 mediates transsynaptic assembly with photoreceptors through interaction with the extracellular matrix protein pikachurin, aligning neurotransmitter release apparatus with postsynaptic signaling cascades 2. Unlike canonical GPCRs, GPR179 functions as an atypical GPCR that recruits and regulates R7 RGS-GNB5 complexes, promoting GTPase activity of G protein alpha subunits and controlling the gating of TRPM1 channels 3. Structurally, GPR179 forms homodimers through an unusual TM1/7 interface with a disulfide bond, adopting a noncanonical architecture suited for the curved membrane of dendritic tips 4. Mutations in GPR179 cause complete congenital stationary night blindness (cCSNB), characterized by complete loss of night vision and ON-bipolar cell signaling defects 3. cCSNB associated with GPR179 mutations is also linked to high myopia, suggesting GPR179's broader role in retinal development 5. GPR179 represents an attractive therapeutic target for blinding disorders affecting visual signal transmission.