GPR37L1 is a G protein-coupled receptor predominantly expressed in glial cells, particularly satellite glial cells (SGCs) in dorsal root ganglia and Bergmann glia astrocytes in the cerebellum 12. The receptor functions as a constitutively active GPCR coupled to Gs proteins 3. Recent evidence identifies maresin 1, a pro-resolving lipid mediator, as a GPR37L1 ligand that enhances potassium channel activity (KCNJ10/Kir4.1 and KCNJ3/Kir3.1) in SGCs, promoting pain resolution 1. Additionally, macrophage-derived prosaposin activates GPR37L1 on SGCs to support axon regeneration following nerve injury 4. In the CNS, GPR37L1 regulates astrocyte maturation and morphological organization during development 2. The receptor also participates in neuroprotection via the PSAP-GPR37L1 pathway in astrocytes, potentially mitigating Parkinson's disease pathogenesis 5. Clinically, rare GPR37L1 coding variants are associated with progressive myoclonus epilepsy and neuropsychiatric conditions including anxiety disorders and migraine, with variants exhibiting altered cAMP and MAPK signaling 67. GPR37L1 also regulates baseline blood pressure, particularly in females 8. These functions position GPR37L1 as a promising therapeutic target for neuropathic pain, nerve regeneration, and neurodegenerative diseases.