GPRASP3 is a G protein-coupled receptor associated sorting protein family member located on the X chromosome X functions as a survival and differentiation-promoting protein 1. As part of GPRASP subfamily 1, GPRASP3 contains armadillo-like repeats and is implicated in neurosynaptogenesis regulation 1. The protein exerts neuroprotective effects through phosphatase PP2A activation, leading to APP dephosphorylation and inhibition of BACE1-mediated amyloidogenic processing [UniProt annotation supported by 2 demonstrating PP2A interaction in neuroprotection]. GPRASP3 promotes dendritic spine morphogenesis, neurogenesis, and synapse assembly while preventing neuronal apoptosis [GO annotations]. The protein's involvement in APP metabolism and anti-apoptotic signaling implicates GPRASP3 in Alzheimer's disease pathogenesis, where dysregulation of amyloid-β processing is central 3. Clinically, deletion of GPRASP family members causes severe neurodevelopmental impairment and intellectual disability in humans, underscoring GPRASP3's essential role in neuronal development and survival 1. Additionally, p60TRP (related to GPRASP function) shows altered expression in Alzheimer's brains and potential involvement in cancer-associated mutations 24. Further investigation of GPRASP3-specific mutations and PP2A interactions may reveal therapeutic targets for neurodegenerative diseases.