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GeneE
1 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
LRRC24
leucine rich repeat containing 24
Chromosome 8 Β· 8q24.3
NCBI Gene: 441381Ensembl: ENSG00000254402.7HGNC: HGNC:28947UniProt: Q50LG9
11PubMed Papers
9Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
signaling receptor activitypositive regulation of synapse assemblyplasma membraneexternal side of plasma membraneintelligenceattention deficit hyperactivity disorderrisk-taking behaviourDravet syndrome
✦AI Summary

Based on limited published evidence, LRRC24 is a leucine-rich repeat protein localized to the external plasma membrane with predicted signaling receptor activity and roles in synapse assembly regulation. The primary published finding identifies LRRC24 natural antisense RNA within exosomes secreted from colorectal cancer cell lines, which can be transferred to hepatoma and lung cancer cells 1. This suggests potential involvement in intercellular communication through exosomal RNA transfer, though direct protein function remains largely uncharacterized.

Sources cited
1
LRRC24 natural antisense RNA is detected in exosomes from colorectal cancer cells and can be transferred to recipient cancer cells
PMID: 22895844
⚠Limited data available β€” This gene has 1 indexed publication. Summary and analysis may be incomplete.
Disease Associationsβ“˜9
intelligenceOpen Targets
0.04Suggestive
attention deficit hyperactivity disorderOpen Targets
0.03Suggestive
risk-taking behaviourOpen Targets
0.02Suggestive
Dravet syndromeOpen Targets
0.01Suggestive
colorectal carcinomaOpen Targets
0.01Suggestive
Neurodevelopmental disorderOpen Targets
0.00Suggestive
ovarian cancerOpen Targets
0.00Suggestive
hepatocellular carcinomaOpen Targets
0.00Suggestive
ovarian serous cystadenocarcinomaOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
LRRTM4Shared pathway100%LRRTM1Shared pathway100%LRRTM3Shared pathway33%CLSTN3Shared pathway33%SLITRK5Shared pathway33%SLITRK6Shared pathway33%
Tissue Expression6 tissues
Brain
100%
Ovary
2%
Liver
1%
Lung
1%
Heart
0%
Bone Marrow
0%
Gene Interaction Network
Click a node to explore
LRRC24LRRTM4LRRTM1LRRTM3CLSTN3SLITRK5SLITRK6
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt Q50LG9
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.89LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF1.40 [0.95–1.89]
RankingsWhere LRRC24 stands among ~20K protein-coding genes
  • #16,815of 20,598
    Most Researched11
  • #17,183of 17,882
    Most Constrained (LOEUF)1.89
Genes detectedLRRC24
Sources retrieved1 papers
Response timeβ€”
πŸ“„ Sources
1
1
Exosomes secreted from human colorectal cancer cell lines contain mRNAs, microRNAs and natural antisense RNAs, that can transfer into the human hepatoma HepG2 and lung cancer A549 cell lines.
PMID: 22895844
Oncol Rep Β· 2012
1.00