SLITRK5 (SLIT and NTRK like family member 5) is a transmembrane protein widely expressed in the central nervous system that functions as a key regulator of synaptic development and signaling. The protein contains leucine-rich repeats (LRRs) in its extracellular domain and tyrosine residues in its intracellular domain, enabling diverse regulatory functions 1. SLITRK5 promotes inhibitory synapse formation on dopamine neurons while suppressing neurite outgrowth, with its loss leading to excessive grooming behaviors reminiscent of obsessive-compulsive disorder in mouse models 2 3. The protein acts as a negative regulator of hedgehog signaling in osteoblasts by binding hedgehog ligands and interacting with PTCH1, thereby controlling bone formation 4. SLITRK5 is implicated in various neuropsychiatric conditions, with upregulation observed in epilepsy patients and animal models 5 and dysregulation noted in Friedreich ataxia 6. However, genetic association studies have not found evidence linking SLITRK5 variants to Tourette syndrome 7. The protein's role in synaptic adhesion, neuron differentiation, and synaptogenesis positions it as a potential therapeutic target for central nervous system disorders characterized by synaptic dysfunction.