SLITRK1 encodes a neuronal transmembrane protein that plays critical roles in synapse development and neural circuit formation. The protein promotes excitatory synapse differentiation and is specifically localized to excitatory synapses, where overexpression increases synaptic contacts while knockdown reduces excitatory synapse formation 1. SLITRK1 enhances neuronal dendrite outgrowth through phosphorylation-dependent mechanisms involving 14-3-3 protein binding and regulation by protein kinases including PKA, PKC, and casein kinase II 2. A key developmental function involves suppressing noradrenergic projections in the neonatal prefrontal cortex through interactions with Semaphorin3A signaling pathways 3. SLITRK1 deficiency in mice causes neonatal noradrenergic system dysregulation, excessive noradrenergic fiber growth, and later anxiety-like behaviors 4. Clinically, rare variants in SLITRK1 are associated with obsessive-compulsive spectrum disorders including Tourette syndrome, trichotillomania, and obsessive-compulsive disorder 4. Specific mutations like S330A and A444S impair protein function and are linked to schizophrenia and bipolar disorder respectively 3. Genetic association studies have identified SLITRK1 variants linked to specific OCD symptom dimensions, particularly checking behaviors in males 5. These findings collectively establish SLITRK1 as a critical regulator of neural development with significant implications for neuropsychiatric disorders.