GRK1 (G protein-coupled receptor kinase 1) is a retina-specific kinase that phosphorylates rhodopsin to terminate phototransduction signaling 1. This rapid desensitization of the activated rhodopsin receptor is essential for scotopic vision and enables quick adaptation to changes in light illumination 2. GRK1 functions as part of a negative feedback loop in vertebrate phototransduction, with its activity regulated in a calcium-dependent manner by the protein recoverin 2. The kinase operates through multipoint substrate attachment mechanisms independent of second messengers 1. Pathogenic variants in GRK1 cause Oguchi disease, a rare autosomal recessive form of congenital stationary night blindness (CSNB) 34. Clinical manifestations include severe night blindness, characteristic fundus appearance (Mizuo-Nakamura phenomenon), attenuated rod electroretinogram responses, and negative ERG waveforms, while visual acuity and visual fields typically remain normal 3. GRK1 mutations account for a significant portion of inherited retinal disease cases 5. Structurally, disease-causing variants show a hotspot in the kinase domain 4. GRK1 serves as a promoter element in gene therapy applications for retinal photoreceptor diseases 6, and the protein interacts with the molecular chaperone Hsp90 to maintain retinal proteostasis 7.