GSC2 (goosecoid homeobox 2) is a DNA-binding transcription factor located on chromosome 22.2 that functions in developmental regulation. As a sequence-specific DNA-binding protein, GSC2 likely regulates transcription through RNA polymerase II and may bind the bicoid consensus sequence TAATCC, with evidence suggesting it can regulate its own transcription 1. GSC2 is responsive to cellular stress responses; specifically, it is induced downstream of Ca2+ signaling through Crz1 transcription factor activation during arsenic stress in eukaryotic cells, with PMR1, PMC1, and GSC2 representing endogenous targets of this pathway 2. Clinically, GSC2 is implicated in oculo-auriculo-vertebral spectrum (OAVS/hemifacial microsomia), a congenital condition affecting first and second pharyngeal arch development. A systematic review identified GSC2 as a candidate gene for OAVS in the 22q11.2 region, alongside other genes including TBX1 and HIRA, though no single gene has been confirmed as causative 1. The gene's involvement in early embryonic development is underscored by its identification as a novel goosecoid-like homeobox gene in syntenic mouse chromosome 22 regions corresponding to DiGeorge/velocardiofacial syndrome loci 3. Further research into gene interactions within the 22q11 region is necessary to establish definitive genotype-phenotype correlations.