GSDMC (gasdermin C) is a pore-forming protein that executes pyroptosis, a programmed necrotic cell death critical for immune defense 1. GSDMC is activated through proteolytic cleavage by caspase-8 in response to death signals 23. Following cleavage, the N-terminal domain translocates to the plasma membrane where it binds phosphoinositide lipids and forms 10-15 nm diameter pores through homooligomerization, triggering pyroptotic cell lysis 42. GSDMC participates in multiple inflammatory pathways: the caspase-8/GSDMC axis operates in both cancer cells and intestinal epithelial cells during inflammation 25. In pancreatic cancer, GSDMC promotes stemness and immune evasion through a pyroptosis-independent mechanism involving ADAM17-mediated cleavage and nuclear translocation 6. In intestinal immunity, cathepsin S-cleaved GSDMC targets Rab7+ vesicles rather than the plasma membrane, modulating lipid metabolism and promoting anti-helminth type 2 responses 7. Dysregulated pyroptosis involving GSDMC contributes to disease pathogenesis in sepsis, atherosclerosis, respiratory disease, and inflammatory bowel disease 185. High GSDMC expression correlates with poor cancer survival, suggesting therapeutic potential for targeting this pathway in cancer and inflammatory diseases.