H2AC14 (H2A clustered histone 14) is a core nucleosomal histone protein located on chromosome 6 that functions as a structural component of chr6. As part of the histone octamer, H2AC14 wraps and compacts DNA into nucleosomes, thereby regulating DNA accessibility for cellular processes including transcription, DNA repair, and replication 1. The protein's function is modulated through post-translational modifications and nucleosome remodeling, collectively forming the "histone code" that controls chr6 dynamics. Clinically, H2AC14 has emerged as a biomarker in multiple disease contexts. In preclinical Alzheimer's disease, elevated expression of a histone gene cluster module containing H2AC14 on chromosome 6 associates with lower brain amyloid burden, implicating this histone in amyloid-related pathology 1. In colorectal cancer, H2AC14 is significantly overexpressed and correlates with TNM staging, prognosis, and overall survival 2. Mechanistically, H2AC14 promotes epithelial-mesenchymal transition and tumor metastasis in CRC cells, with silencing reducing migration speed 2. Additionally, H2AC14 functions as a core regulatory gene in pulpitis pathogenesis, participating in a ceRNA network involving circular RNAs and microRNAs in inflammatory responses 3. These findings establish H2AC14 as both a fundamental chr6 structural protein and a potential therapeutic target in cancer and neurodegenerative diseases.