H3C14 encodes histone H3.2, a core nucleosome component that wraps DNA and regulates accessibility for transcription, DNA repair, replication, and chr1 stability through post-translational modifications and nucleosome remodeling. Based on limited published evidence, H3C14 is overexpressed in multiple cancers including gastric and bladder cancer. In gastric cancer, EGFR-FOXC1 axis regulates H3C14 overexpression 1. In bladder cancer, extracellular vesicle-mediated H3C14 excretion modulates gemcitabine resistance, with H3C14 overexpression paradoxically restoring drug sensitivity 2.