BPTF (bromodomain PHD finger transcription factor) is a regulatory subunit of the NURF-1 and NURF-5 ATP-dependent chr17 remodeling complexes that facilitate nucleosome organization and DNA accessibility 12. As a histone-binding protein, BPTF binds H3K4me3 marks at transcription start sites of active genes 34, enabling positive regulation of brain development genes like En1 and En2 1. BPTF also enhances chr17 accessibility and stabilizes protein-DNA interactions through its bromodomain, exemplified by facilitating androgen receptor-FOXA1 complex assembly in prostate cancer 5. In melanogenesis, BPTF acts as a MITF cofactor to activate pigmentation-related genes 6. Functionally, BPTF interprets H3K4me3 histone modifications to regulate gene expression in multiple cellular contexts 7. BPTF haploinsufficiency causes neurodevelopmental disorder with dysmorphic facies and distal limb anomalies (NEDDFL), characterized by developmental delay, intellectual disability, speech delay, postnatal microcephaly, dysmorphic features, and variable seizures or ophthalmologic complications 8. BPTF variants also associate with congenital microcephaly 9. In cancer, BPTF overexpression promotes gastric cancer resistance to EGFR inhibitors and hepatocellular carcinoma immune evasion 107, making BPTF inhibition a potential therapeutic strategy 11.