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GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
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MATCAP1
microtubule associated tyrosine carboxypeptidase 1
Chromosome 16 Β· 16q22.1
NCBI Gene: 653319Ensembl: ENSG00000196123.14HGNC: HGNC:34408UniProt: Q68EN5
9PubMed Papers
12Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Protease
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
microtubuleprotein bindingtubulin-tyrosine carboxypeptidase activitymetallocarboxypeptidase activitylacrimal apparatus diseasechronic kidney diseaseataxia telangiectasiaPick disease
✦AI Summary

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microtubule associated tyrosine carboxypeptidase 1

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜12
lacrimal apparatus diseaseOpen Targets
0.02Suggestive
chronic kidney diseaseOpen Targets
0.01Suggestive
ataxia telangiectasiaOpen Targets
0.01Suggestive
Pick diseaseOpen Targets
0.01Suggestive
viral myocarditisOpen Targets
0.00Suggestive
type 2 diabetes mellitusOpen Targets
0.00Suggestive
cervical cancerOpen Targets
0.00Suggestive
gastric cancerOpen Targets
0.00Suggestive
Hereditary breast cancerOpen Targets
0.00Suggestive
hereditary breast carcinomaOpen Targets
0.00Suggestive
melanomaOpen Targets
0.00Suggestive
ovarian serous cystadenocarcinomaOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
FOXG1Shared pathway100%VCYShared pathway100%PHGDHShared pathway100%VCX2Shared pathway100%VCX3AShared pathway100%CA10Shared pathway100%
Tissue Expression6 tissues
Ovary
100%
Bone Marrow
28%
Liver
25%
Lung
25%
Heart
16%
Brain
11%
Gene Interaction Network
Click a node to explore
MATCAP1FOXG1VCYPHGDHVCX2VCX3ACA10
PROTEIN STRUCTURE
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PDB7Z5G Β· 2.11 Γ… Β· X-ray
View on RCSB β†—
Constraintβ“˜
LOEUFβ“˜
0.97LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF0.71 [0.52–0.97]
RankingsWhere MATCAP1 stands among ~20K protein-coding genes
  • #17,373of 20,598
    Most Researched9
  • #9,173of 17,882
    Most Constrained (LOEUF)0.97
Genes detectedMATCAP1
Sources retrieved0 papers
Response timeβ€”