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10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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VCY
variable charge Y-linked
Chromosome Y · Yq11.221
NCBI Gene: 9084Ensembl: ENSG00000129862.7HGNC: HGNC:12668UniProt: O14598
15PubMed Papers
5Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingbrain developmentazoospermiaprostate cancerneoplasmgonadoblastoma
✦AI Summary

Based on the provided abstracts, VCY (Variable Charge Y-linked) is a Y chrY-specific gene that exists in multiple copies within palindromic structures 1. The gene family originated from proto-X/Y gene pairs in ancestral mammalian sex chrY, with VCY having functional X-linked gametologs 23. VCY is located within the P8 palindrome on the human Y chrY, where structural variations can result in healthy men having 1-4 copies of the gene 1. The palindromic structure undergoes frequent gene conversion between arms to maintain sequence identity, though copies at different positions within palindromes can be distinctively different 2. Evolutionary analysis indicates that VCY duplications occurred in the human lineage after the human-chimpanzee split, with accumulated substitutions allowing identification of these duplicates 3. The gene appears to be subject to rapid evolutionary changes, as palindromic structures containing VCY show remarkable lability over time, with mechanisms including deletion of palindrome arms, size increases through sequence recruitment, and formation of new palindromes 1. However, the provided abstracts do not contain sufficient information about VCY's specific molecular function, mechanism of action, or direct disease associations to make definitive statements about these aspects.

Sources cited
1
VCY is located in palindromic structures on Y chromosome and healthy men can have 1-4 copies
PMID: 31610793
2
VCY originated from proto-X/Y gene pairs and has functional X-linked gametologs
PMID: 17185645
3
VCY has functional X gametologs and underwent duplication in human lineage
PMID: 17183480
4
VCY-containing palindromes undergo structural variations including deletions and duplications
PMID: 31610793
5
Gene conversion maintains palindromic structure but copies at different positions are distinctively different
PMID: 17185645
Disease Associationsⓘ5
azoospermiaOpen Targets
0.01Suggestive
prostate cancerOpen Targets
0.00Suggestive
gonadoblastomaOpen Targets
0.00Suggestive
neoplasmOpen Targets
0.00Suggestive
posterior cortical atrophyOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
FOXG1Shared pathway100%MATCAP1Shared pathway100%VCX3BShared pathway100%FOXR1Shared pathway100%DNAJC30Shared pathway100%CA10Shared pathway100%
Tissue Expression6 tissues
Liver
0%
Ovary
0%
Brain
0%
Heart
0%
Lung
0%
Bone Marrow
0%
Gene Interaction Network
Click a node to explore
VCYFOXG1MATCAP1VCX3BFOXR1DNAJC30CA10
PROTEIN STRUCTURE
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AlphaFoldAI-predicted · UniProt O14598
View on AlphaFold ↗
RankingsWhere VCY stands among ~20K protein-coding genes
  • #15,732of 20,598
    Most Researched15
Genes detectedVCY
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Copy-Years Viremia and Risk of Virological Failure in Long-Term-Treated HIV Patients.
PMID: 30531307
J Acquir Immune Defic Syndr · 2019
1.00
2
Birth, expansion, and death of VCY-containing palindromes on the human Y chromosome.
PMID: 31610793
Genome Biol · 2019
0.90
3
Cumulative Human Immunodeficiency Virus (HIV)-1 Viremia Is Associated With Increased Risk of Multimorbidity Among US Women With HIV, 1997-2019.
PMID: 36751648
Open Forum Infect Dis · 2023
0.80
4
Viral load monitoring and antiretroviral treatment outcomes in a pediatric HIV cohort in Ghana.
PMID: 26843068
BMC Infect Dis · 2016
0.70
5
The origin and evolution of human ampliconic gene families and ampliconic structure.
PMID: 17185645
Genome Res · 2007
0.60