VCX2 (variable charge X-linked 2) is an X-linked gene whose primary function remains incompletely characterized, though it may participate in spermatogenesis or sex ratio distortion based on UniProt annotations. VCX2 is located on chromosome X.3 within a region containing other variable charge family members and is subject to structural variation. The gene has been identified as a differentially expressed gene in molecular network analyses distinguishing idiopathic pulmonary fibrosis from lung squamous cell carcinoma, suggesting potential involvement in pulmonary pathology 1. VCX2 is located adjacent to functionally characterized genes including STS (steroid sulfatase); large genomic deletions encompassing VCX2 have been identified in patients with X-linked ichthyosis, though VCX2 deletion alone does not appear causative for the associated mental retardation phenotype 2, 3. A 4.8 Mb deletion involving VCX2 and multiple flanking genes (including ANOS1, VCX3B, PNPLA4, VCX, STS, HDHD1, VCX3A, and NLGN4X) was identified in a patient with Kallmann syndrome and ichthyosis 4, indicating VCX2 may contribute to pleiotrophic phenotypes when deleted in concert with adjacent genes. GO annotations suggest possible involvement in brain development, though direct evidence for this function is limited.