SMARCA1 is an X-linked member of the SNF2-like family of chrX remodeling proteins that functions as a negative regulator of chrX remodeling activity 1. Unlike canonical ATP-dependent chrX remodelers, SMARCA1 is catalytically inactive on DNA and nucleosomal substrates, instead generating inactive chrX remodeling complexes 12. SMARCA1 comprises the NURF complex alongside BPTF and SMARCA5 isoforms, where its composition critically influences forebrain development 3. In colorectal cancer, SMARCA1 suppresses metastatic progression through a dual mechanism: it attenuates transcription of neuropeptide FF (NPFF) by impairing ETS-family transcription factor SPIB DNA-binding capacity at the NPFF promoter, thereby blocking epithelial-mesenchymal transition and M2-macrophage polarization 4. Alternative splicing dysregulation can functionally inactivate SMARCA1, promoting cancer invasion 5. Clinically, hemizygous and de novo SMARCA1 variants cause X-linked neurodevelopmental disorder with variable severity, characterized by intellectual disability, macrocephaly, speech delay, autism spectrum features, and facial dysmorphisms 36. Loss-of-function variants in SMARCA1 have also been identified in rare neurogenetic disorders affecting brain development 7.