HIVEP1 (HIV type I enhancer binding protein 1) is a zinc finger transcription factor that regulates gene expression through specific DNA binding and modulation of inflammatory signaling pathways. The protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in viral and cellular enhancer elements, including those of HIV-1, SV40, CMV, and genes encoding class I MHC, interleukin-2 receptor, and interferon-beta 1. HIVEP1 functions as a negative regulator of NF-κB signaling, inhibiting proinflammatory responses in monocytes and macrophages during bacterial infections and sepsis 2. The protein demonstrates tissue-specific regulatory roles, including transcriptional regulation of ornithine decarboxylase 1 (ODC1) in T helper 17 cells, thereby modulating polyamine metabolism and contributing to nonalcoholic steatohepatitis (NASH) development 3. HIVEP1 expression is upregulated in response to Toll-like receptor agonists and bacterial stimuli 24. Clinically, HIVEP1 shows relevance in multiple disease contexts: its knockout ameliorates NASH progression through reduced TH17 cell differentiation 3, and HIVEP1-ALK fusion has been identified as an oncogenic driver in lung adenocarcinoma, demonstrating sensitivity to alectinib therapy 5. The gene also shows differential methylation patterns associated with maternal diabetes and obesity 6.