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GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
ⓘGeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
HPN
hepsin
Chromosome 19 · 19q13.11
NCBI Gene: 3249Ensembl: ENSG00000105707.16HGNC: HGNC:5155UniProt: A0A140VJK9
76PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Protease
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
nuclear membraneserine-type endopeptidase activityprotein bindingpeptidase activityneuroinflammatory disorderAbnormality of the skeletal systematrial fibrillationprostate cancer
✦AI Summary

Based on the provided abstracts, there is insufficient information about the HPN (hepsin) gene function. The abstracts primarily discuss home parenteral nutrition (HPN) and hereditary peripheral neuropathy (HPN), with one abstract describing an Hpn protein in Helicobacter pylori 1. The H. pylori Hpn is described as a 60-amino acid, histidine-rich protein that binds nickel and zinc ions and affects bacterial susceptibility to metal ions including bismuth 1. However, this bacterial protein appears unrelated to the human HPN (hepsin) gene located on chromosome 19. The remaining abstracts focus on clinical aspects of parenteral nutrition and peripheral neuropathy conditions, which do not provide relevant information about the molecular function, mechanism, disease relevance, or clinical significance of the human hepsin gene. Without appropriate abstracts containing information about human hepsin's serine protease activity, substrate processing capabilities, or roles in cell growth and maintenance, a comprehensive gene function summary cannot be generated from the provided literature.

Sources cited
1
Describes H. pylori Hpn as a histidine-rich protein that binds nickel and zinc ions and affects metal ion susceptibility
PMID: 10469190
⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
Disease Associationsⓘ20
neuroinflammatory disorderOpen Targets
0.27Weak
Abnormality of the skeletal systemOpen Targets
0.19Weak
atrial fibrillationOpen Targets
0.15Weak
prostate cancerOpen Targets
0.10Weak
hepatocellular carcinomaOpen Targets
0.10Weak
neoplasmOpen Targets
0.10Suggestive
breast cancerOpen Targets
0.08Suggestive
hypertriglyceridemia 2Open Targets
0.08Suggestive
gastric cancerOpen Targets
0.07Suggestive
pancreatic triacylglycerol lipase deficiencyOpen Targets
0.07Suggestive
familial hypercholesterolemiaOpen Targets
0.07Suggestive
thyroid hormone metabolism, abnormal, 2Open Targets
0.07Suggestive
Combined hyperlipidemiaOpen Targets
0.06Suggestive
sitosterolemia 2Open Targets
0.06Suggestive
homozygous familial hypercholesterolemiaOpen Targets
0.06Suggestive
autosomal dominant nonsyndromic hearing lossOpen Targets
0.06Suggestive
posterior cortical atrophyOpen Targets
0.05Suggestive
colorectal cancerOpen Targets
0.05Suggestive
deafnessOpen Targets
0.05Suggestive
hypercholesterolemia, autosomal dominant, 3Open Targets
0.05Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
SPINT1Protein interaction94%IGLL5Protein interaction91%MST1Protein interaction83%AMACRProtein interaction75%ADAM19Shared pathway16%F12Shared pathway14%
Tissue Expression6 tissues
Liver
100%
Lung
1%
Heart
0%
Brain
0%
Ovary
0%
Bone Marrow
0%
Gene Interaction Network
Click a node to explore
HPNSPINT1IGLL5MST1AMACRADAM19F12
PROTEIN STRUCTURE
Preparing viewer…
PDB1Z8G · 1.55 Å · X-ray
View on RCSB ↗
Constraintⓘ
LOEUFⓘ
0.40Moderately Constrained
pLIⓘ
1.00Intolerant
Observed/Expected LoF0.25 [0.16–0.40]
RankingsWhere HPN stands among ~20K protein-coding genes
  • #6,251of 20,598
    Most Researched76
  • #1,971of 17,882
    Most Constrained (LOEUF)0.40 · top quartile
Genes detectedHPN
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Parenteral nutrition at home/long-term parenteral nutrition.
PMID: 38527076
Am J Health Syst Pharm · 2024
1.00
2
Parenteral Nutrition and Intestinal Failure.
PMID: 28481229
Nutrients · 2017
0.90
3
Cost analysis of chronic intestinal failure.
PMID: 30115462
Clin Nutr · 2019
0.80
4
Quality of life after intestinal transplantation.
PMID: 33595982
Curr Opin Organ Transplant · 2021
0.70
5
Challenges and Obstacles of Long-Term Home Parenteral Nutrition.
PMID: 30714635
Nutr Clin Pract · 2019
0.60