IFIT1 (interferon-induced protein with tetratricopeptide repeats 1) is a key antiviral effector protein that functions as part of an interferon-dependent innate immune response mechanism 1. Its primary function involves recognizing and sequestering viral RNAs lacking host-specific 2'-O-methylation at their 5' cap structure, thereby inhibiting their translation by competing with translation initiation factor eIF4E 2. IFIT1 works synergistically with IFIT3, which stabilizes IFIT1 and enhances its specificity for unmethylated cap structures 2. The protein exhibits broad antiviral activity against multiple virus families including Flaviviridae, Coronaviridae, and Poxviridae. IFIT1 is transcriptionally induced by interferons, viral infection, and molecular patterns such as double-stranded RNA 1. In autoimmune contexts, IFIT1 is significantly upregulated in systemic lupus erythematosus and primary Sjögren's syndrome, where it participates in interferon response pathways driven by dysregulated type I interferon signaling 34. Beyond immune functions, IFIT1 promotes pancreatic cancer proliferation and invasion through Wnt/β-catenin pathway activation 5. Recent evidence indicates IFIT1 also orchestrates programmed cell death in hematological malignancies through pyroptosis induction 6.