IFT70B — intraflagellar transport 70B

5 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

17PubMed Papers

#15,108 · top 78% of 19K genes

13Diseases

top 93%

0Drugs

0Pathogenic Variants

Experimental GO EvidenceSwiss-Prot Reviewed

intraciliary transport particle Aprotein bindingintraciliary transportaxonemal microtubulesynpolydactylyliver diseaseAbnormality of the skeletal systemneuronal ceroid lipofuscinosis 1

AI Summary

AI summary not yet available. Showing NCBI Gene summary.

intraflagellar transport 70B

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations13

synpolydactylyOpen Targets

0.12Weak

liver diseaseOpen Targets

0.04Suggestive

Abnormality of the skeletal systemOpen Targets

0.04Suggestive

neuronal ceroid lipofuscinosis 1Open Targets

0.04Suggestive

familial isolated congenital aspleniaOpen Targets

0.04Suggestive

diabetes mellitusOpen Targets

0.04Suggestive

cervical carcinomaOpen Targets

0.03Suggestive

obstructive sleep apneaOpen Targets

0.03Suggestive

ependymomaOpen Targets

0.02Suggestive

insomniaOpen Targets

0.02Suggestive

childhood supratentorial ependymomaOpen Targets

0.02Suggestive

Platelet storage pool diseaseOpen Targets

0.01Suggestive

ciliopathyOpen Targets

0.00Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression6 tissues

Brain

100%

Bone Marrow

45%

Heart

38%

Liver

27%

Ovary

25%

Lung

22%

Gene Interaction Network6 neighbors

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StructureAlphaFold

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AlphaFoldAI-predicted · UniProt Q8N4P2

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ConstraintgnomAD v4.1

LOEUFⓘ

0.95LoF Tolerant

pLIⓘ

0.00Tolerant

Observed/Expected LoF0.70 [0.53–0.95]

Rankings2 dim

Where IFT70B stands among ~20K protein-coding genes

#15,022of 20,598
Most Researched17
#8,837of 17,882
Most Constrained (LOEUF)0.95