Integrin-linked kinase (ILK) is a multifunctional scaffold protein mediating cell-matrix interactions and dynamic adhesion events 1. As a key component of the ILK-PINCH-PARVIN (IPP) complex, ILK recruits PARVA and LIMS1 to promote F-actin filament bundling, facilitating cytoskeletal reorganization and cell spreading/migration 2. ILK binding to PARVA enables focal adhesion assembly while simultaneously engaging integrin-beta cytoplasmic tails to mediate cell adhesion 2. Beyond structural roles, ILK acts as an upstream effector of AKT1/PKB and GSK3 signaling pathways 1 and regulates the CCDC25-ILK-PKCα pathway in immune contexts 3. ILK is essential for maintaining mitotic spindle integrity and endothelial homeostasis, preventing endothelial-to-mesenchymal transition 4. Clinically, ILK dysfunction contributes to disease pathogenesis across multiple systems. In asthma, eosinophil extracellular traps activate pulmonary neuroendocrine cells via the ILK pathway, amplifying allergic responses 3. In cardiovascular disease, endothelial ILK deletion causes microvascular dysfunction, fibrosis, and cardiac remodeling 4. STK10-mediated ILK phosphorylation regulates platelet function and thromboinflammation 5. In cancer, particularly glioblastoma, an ILK/STAT3 pathway controls stem cell plasticity and mesenchymal-invasive phenotypes 6. However, ILK's catalytic kinase activity remains controversial 1.