PXN (paxillin) encodes a 68 kDa cytoplasmic adapter protein that localizes to focal adhesions, serving as a critical scaffold for cell-matrix interactions 1. The protein functions by recruiting structural and signaling molecules including vinculin, FAK, PYK2, Src, and Crk to focal adhesion sites, where it undergoes phosphorylation in response to integrin-mediated cell adhesion and growth factor stimulation 1. This scaffolding activity facilitates efficient processing of external stimuli that regulate cell adhesion, motility, and growth control 1. PXN demonstrates significant clinical relevance across multiple cancer types, with higher expression generally correlating with poor overall and disease-free survival 2. The protein contributes to cancer progression through various mechanisms, including regulation of PD-L1 expression via CXCL5-mediated Paxillin/AKT signaling in lung cancer 3, and modulation of focal adhesion signaling that affects cell migration 4. Additionally, PXN undergoes post-translational modifications such as K6-linked ubiquitination at lysine 68 in the δ isoform, which regulates viral entry processes 5. The gene's antisense transcript PXN-AS1 also plays oncogenic roles in hepatocellular carcinoma metastasis and is upregulated in pituitary adenomas 67.